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In vitro binding studies show Cardizem is 70% to 80% bound to plasma proteins. Dermatological events (see ADVERSE REACTIONS section) may be transient and may disappear despite continued use of Cardizem. Experience with the use of Cardizem alone or in combination with beta-blockers in patients with impaired ventricular function is very limited. Spontaneous and ergonovine-induced coronary artery spasm are inhibited by Cardizem. Single oral doses of 30 to 120 mg of Cardizem tablets result in detectable plasma levels within 30 to 60 minutes and peak plasma levels 2 to 4 hours after drug administration.

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